GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs12762955 | 1 | rs12777800 | chr10:1070361 | IDI2 | chr10:1064847-1071799:- | -0.18 | -3.46 | 0.000571 | Response to angiotensin II receptor blocker therapy |
| BRCA | cis | rs17112901 | 1 | rs12781019 | chr10:102057568 | PKD2L1 | chr10:102047903-102090243:- | 0.22 | 4.18 | 3.13E-5 | Obesity-related traits |
| BRCA | cis | rs6583954 | 1 | rs12781477 | chr10:96472925 | HELLS | chr10:96305543-96361855:+ | 0.12 | 3.44 | 0.000595 | Migraine |
| BRCA | cis | rs7927771 | 1 | rs12787330 | chr11:47812311 | MADD | chr11:47290927-47351582:+ | 0.15 | 4.51 | 7.35E-6 | Subjective well-being |
| BRCA | cis | rs7927771 | 1 | rs12787330 | chr11:47812311 | MYBPC3 | chr11:47352958-47374253:- | -0.14 | -4.27 | 2.12E-5 | Subjective well-being |
| BRCA | cis | rs12787909 | 1 | rs12787909 | chr11:117546482 | ARCN1 | chr11:118443102-118473745:+ | 0.2 | 3.41 | 0.00067 | Lipoprotein (a) - cholesterol levels |
| BRCA | cis | rs12787909 | 1 | rs12787909 | chr11:117546482 | ATP5L | chr11:118272104-118280561:+ | 0.28 | 5.66 | 1.93E-8 | Lipoprotein (a) - cholesterol levels |
| BRCA | cis | rs12787909 | 1 | rs12787909 | chr11:117546482 | CEP164 | chr11:117192432-117283980:+ | 0.29 | 4.74 | 2.46E-6 | Lipoprotein (a) - cholesterol levels |
| BRCA | cis | rs12787909 | 1 | rs12787909 | chr11:117546482 | MLL | chr11:118307205-118397538:+ | 0.16 | 3.58 | 0.000358 | Lipoprotein (a) - cholesterol levels |
| BRCA | cis | rs12787909 | 1 | rs12787909 | chr11:117546482 | RNF214 | chr11:117103404-117156402:+ | 0.35 | 5.15 | 3.18E-7 | Lipoprotein (a) - cholesterol levels |
| BRCA | cis | rs12787909 | 1 | rs12787909 | chr11:117546482 | TMEM25 | chr11:118401803-118417313:+ | 0.21 | 4.08 | 4.87E-5 | Lipoprotein (a) - cholesterol levels |
| BRCA | cis | rs12787909 | 1 | rs12787909 | chr11:117546482 | UBE4A | chr11:118230302-118269924:+ | 0.25 | 4.26 | 2.27E-5 | Lipoprotein (a) - cholesterol levels |
| BRCA | cis | rs12295403 | 1 | rs12789252 | chr11:18690389 | LDHC | chr11:18433853-18472792:+ | -0.2 | -4.73 | 2.59E-6 | Ovarian reserve |
| BRCA | cis | rs1568889 | 1 | rs12790932 | chr11:28046189 | METT5D1 | chr11:28129798-28355054:+ | -0.12 | -3.47 | 0.000545 | Bipolar disorder |
| BRCA | cis | rs1568889 | 1 | rs12791341 | chr11:28335452 | METT5D1 | chr11:28129798-28355054:+ | -0.13 | -3.7 | 0.000224 | Bipolar disorder |